Upstream Bio, Inc. SEC filings UPB
Upstream Bio, Inc. has 134 filings in SEC EDGAR's recent list, going back to Jun 12, 2024. Its latest annual report, Form ARS, was filed on Apr 16, 2026 for the period ended Dec 31, 2025. The latest quarterly report (Form 10-Q) was filed on Aug 11, 2026, covering the quarter ended Jun 30, 2026. The most recent current report (Form 8-K) was filed on Sep 1, 2026 (regulation fd disclosure, other events). The company's fiscal year ends on December 31.
| Form | Description | Filed | Period |
|---|---|---|---|
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Oct 29, 2026 | — |
| 4 | Insider transaction | Sep 17, 2026 | Sep 16, 2026 |
| 4 | Insider transaction | Sep 17, 2026 | Sep 16, 2026 |
| 4 | Insider transaction | Sep 17, 2026 | Sep 16, 2026 |
| 4 | Insider transaction | Sep 17, 2026 | Sep 16, 2026 |
| 4 | Insider transaction | Sep 17, 2026 | Sep 16, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 12, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Jul 30, 2026 | — |
| 4 | Insider transaction | Jun 17, 2026 | Jun 16, 2026 |
| 4 | Insider transaction | Jun 17, 2026 | Jun 16, 2026 |
| 4 | Insider transaction | Jun 17, 2026 | Jun 16, 2026 |
| 4 | Insider transaction | Jun 17, 2026 | Jun 16, 2026 |
| 4 | Insider transaction | Jun 17, 2026 | Jun 16, 2026 |
| 4 | Insider transaction | Jun 11, 2026 | Jun 9, 2026 |
| 4 | Insider transaction | Jun 11, 2026 | Jun 9, 2026 |
| 4 | Insider transaction | Jun 11, 2026 | Jun 9, 2026 |
| 4 | Insider transaction | Jun 11, 2026 | Jun 9, 2026 |
| 4 | Insider transaction | Jun 11, 2026 | Jun 9, 2026 |
| 4 | Insider transaction | Jun 11, 2026 | Jun 9, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | May 15, 2026 | — |
| 4 | Insider transaction | Mar 17, 2026 | Mar 16, 2026 |
| 4 | Insider transaction | Mar 17, 2026 | Mar 16, 2026 |
| 4 | Insider transaction | Mar 17, 2026 | Mar 16, 2026 |
| 4 | Insider transaction | Mar 17, 2026 | Mar 16, 2026 |
| 4 | Insider transaction | Mar 17, 2026 | Mar 16, 2026 |
| 4 | Insider transaction | Jan 6, 2026 | Jan 2, 2026 |
| 4 | Insider transaction | Jan 6, 2026 | Jan 2, 2026 |
| 4 | Insider transaction | Jan 6, 2026 | Jan 2, 2026 |
| 4 | Insider transaction | Jan 6, 2026 | Jan 2, 2026 |
| 4 | Insider transaction | Jan 6, 2026 | Jan 2, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Nov 14, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Nov 14, 2025 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Oct 24, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 6, 2025 | — |
| 4 | Insider transaction | Jun 12, 2025 | Jun 10, 2025 |
| 4 | Insider transaction | Jun 12, 2025 | Jun 10, 2025 |
| 4 | Insider transaction | Jun 12, 2025 | Jun 10, 2025 |
| 4 | Insider transaction | Jun 12, 2025 | Jun 10, 2025 |
| 4 | Insider transaction | Jun 12, 2025 | Jun 10, 2025 |
| 4 | Insider transaction | Jun 12, 2025 | Jun 10, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Feb 14, 2025 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Feb 14, 2025 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Feb 13, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 12, 2025 | — |
| 4 | Insider transaction | Feb 7, 2025 | Feb 6, 2025 |
| 4 | Insider transaction | Feb 7, 2025 | Feb 6, 2025 |
| 4 | Insider transaction | Feb 7, 2025 | Feb 6, 2025 |
| 4 | Insider transaction | Feb 7, 2025 | Feb 6, 2025 |
| 4 | Insider transaction | Feb 7, 2025 | Feb 6, 2025 |
| 4 | Insider transaction | Dec 17, 2024 | Dec 16, 2024 |
| 3 | Initial insider ownership | Dec 17, 2024 | Dec 16, 2024 |
| SC 13G | Ownership over 5% (passive) | Nov 7, 2024 | — |
| SC 13D | Ownership over 5% (active) | Oct 22, 2024 | — |
| SC 13G | Ownership over 5% (passive) | Oct 18, 2024 | — |
| 4 | Insider transaction | Oct 17, 2024 | Oct 15, 2024 |
| 4 | Insider transaction | Oct 17, 2024 | Oct 15, 2024 |
| SC 13D | Ownership over 5% (active) | Oct 17, 2024 | — |
| 4 | Insider transaction | Oct 17, 2024 | Oct 15, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 15, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 10, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 10, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 10, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 10, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 10, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
Showing 78 filings. Main filings leave out insider and ownership forms such as Form 4; choose a type above to see them. Each form opens on SEC.gov. Older filings are on SEC EDGAR.
New to this? Read What Are SEC Filings? 10-K, 10-Q, 8-K and Other Forms Explained.
Company profile
- Industry
- Pharmaceutical Preparations (SIC 2834)
- Listed as
- UPB (Nasdaq)
- Fiscal year ends
- December 31
- Incorporated in
- DE
- Headquarters
- Waltham, MA
- SEC filer status
- , Emerging growth company
- SEC CIK
- 2022626
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Source: SEC EDGAR filings. This is company-reported data, not investment advice.