Upstream Bio, Inc. SEC filings UPB
Upstream Bio, Inc. has 134 filings in SEC EDGAR's recent list, going back to Jun 12, 2024. Its latest annual report, Form ARS, was filed on Apr 16, 2026 for the period ended Dec 31, 2025. The latest quarterly report (Form 10-Q) was filed on Aug 11, 2026, covering the quarter ended Jun 30, 2026. The most recent current report (Form 8-K) was filed on Sep 1, 2026 (regulation fd disclosure, other events). The company's fiscal year ends on December 31.
| Form | Description | Filed | Period |
|---|---|---|---|
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Oct 29, 2026 | — |
| 4 | Insider transaction | Sep 17, 2026 | Sep 16, 2026 |
| 4 | Insider transaction | Sep 17, 2026 | Sep 16, 2026 |
| 4 | Insider transaction | Sep 17, 2026 | Sep 16, 2026 |
| 4 | Insider transaction | Sep 17, 2026 | Sep 16, 2026 |
| 4 | Insider transaction | Sep 17, 2026 | Sep 16, 2026 |
| 8-K |
Current report
Regulation FD disclosure, Other events
|
Sep 1, 2026 | Sep 1, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 12, 2026 | — |
| 10-Q | Quarterly report | Aug 11, 2026 | Jun 30, 2026 |
| 8-K |
Current report
Results of operations
|
Aug 11, 2026 | Aug 11, 2026 |
| SCHEDULE 13G | Ownership over 5% (passive) | Jul 30, 2026 | — |
| 4 | Insider transaction | Jun 17, 2026 | Jun 16, 2026 |
| 4 | Insider transaction | Jun 17, 2026 | Jun 16, 2026 |
| 4 | Insider transaction | Jun 17, 2026 | Jun 16, 2026 |
| 4 | Insider transaction | Jun 17, 2026 | Jun 16, 2026 |
| 4 | Insider transaction | Jun 17, 2026 | Jun 16, 2026 |
| 4 | Insider transaction | Jun 11, 2026 | Jun 9, 2026 |
| 4 | Insider transaction | Jun 11, 2026 | Jun 9, 2026 |
| 4 | Insider transaction | Jun 11, 2026 | Jun 9, 2026 |
| 4 | Insider transaction | Jun 11, 2026 | Jun 9, 2026 |
| 4 | Insider transaction | Jun 11, 2026 | Jun 9, 2026 |
| 4 | Insider transaction | Jun 11, 2026 | Jun 9, 2026 |
| 8-K |
Current report
Shareholder vote results
|
Jun 10, 2026 | Jun 9, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | May 15, 2026 | — |
| 10-Q | Quarterly report | May 13, 2026 | Mar 31, 2026 |
| 8-K |
Current report
Results of operations
|
May 13, 2026 | May 13, 2026 |
| ARS | Annual report to shareholders | Apr 16, 2026 | Dec 31, 2025 |
| DEFA14A | Additional proxy material | Apr 16, 2026 | — |
| DEF 14A | Proxy statement | Apr 16, 2026 | Jun 9, 2026 |
| 8-K |
Current report
Material agreement
|
Mar 26, 2026 | Mar 26, 2026 |
| 424B5 | Prospectus supplement | Mar 26, 2026 | — |
| S-8 | Employee stock plan registration | Mar 26, 2026 | — |
| 10-K | Annual report | Mar 26, 2026 | Dec 31, 2025 |
| 8-K |
Current report
Results of operations
|
Mar 26, 2026 | Mar 26, 2026 |
| 4 | Insider transaction | Mar 17, 2026 | Mar 16, 2026 |
| 4 | Insider transaction | Mar 17, 2026 | Mar 16, 2026 |
| 4 | Insider transaction | Mar 17, 2026 | Mar 16, 2026 |
| 4 | Insider transaction | Mar 17, 2026 | Mar 16, 2026 |
| 4 | Insider transaction | Mar 17, 2026 | Mar 16, 2026 |
| 8-K |
Current report
Results of operations, Regulation FD disclosure
|
Feb 11, 2026 | Feb 11, 2026 |
| 8-K |
Current report
Regulation FD disclosure, Other events
|
Feb 11, 2026 | Feb 11, 2026 |
| 4 | Insider transaction | Jan 6, 2026 | Jan 2, 2026 |
| 4 | Insider transaction | Jan 6, 2026 | Jan 2, 2026 |
| 4 | Insider transaction | Jan 6, 2026 | Jan 2, 2026 |
| 4 | Insider transaction | Jan 6, 2026 | Jan 2, 2026 |
| 4 | Insider transaction | Jan 6, 2026 | Jan 2, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Nov 14, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Nov 14, 2025 | — |
| S-3ASR | Automatic shelf registration | Nov 5, 2025 | — |
| 10-Q | Quarterly report | Nov 5, 2025 | Sep 30, 2025 |
| 8-K |
Current report
Results of operations
|
Nov 5, 2025 | Nov 5, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Oct 24, 2025 | — |
| 8-K |
Current report
Regulation FD disclosure, Other events
|
Sep 2, 2025 | Sep 2, 2025 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 6, 2025 | — |
| 10-Q | Quarterly report | Aug 6, 2025 | Jun 30, 2025 |
| 8-K |
Current report
Results of operations
|
Aug 6, 2025 | Aug 6, 2025 |
| 8-K |
Current report
Shareholder vote results
|
Jun 12, 2025 | Jun 10, 2025 |
| 4 | Insider transaction | Jun 12, 2025 | Jun 10, 2025 |
| 4 | Insider transaction | Jun 12, 2025 | Jun 10, 2025 |
| 4 | Insider transaction | Jun 12, 2025 | Jun 10, 2025 |
| 4 | Insider transaction | Jun 12, 2025 | Jun 10, 2025 |
| 4 | Insider transaction | Jun 12, 2025 | Jun 10, 2025 |
| 4 | Insider transaction | Jun 12, 2025 | Jun 10, 2025 |
| 10-Q | Quarterly report | May 6, 2025 | Mar 31, 2025 |
| 8-K |
Current report
Results of operations
|
May 6, 2025 | May 6, 2025 |
| ARS | Annual report to shareholders | Apr 17, 2025 | Dec 31, 2024 |
| DEFA14A | Additional proxy material | Apr 17, 2025 | — |
| DEF 14A | Proxy statement | Apr 17, 2025 | Jun 10, 2025 |
| S-8 | Employee stock plan registration | Mar 12, 2025 | — |
| 10-K | Annual report | Mar 12, 2025 | Dec 31, 2024 |
| 8-K |
Current report
Results of operations
|
Mar 12, 2025 | Mar 12, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Feb 14, 2025 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Feb 14, 2025 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Feb 13, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 12, 2025 | — |
| 4 | Insider transaction | Feb 7, 2025 | Feb 6, 2025 |
| 4 | Insider transaction | Feb 7, 2025 | Feb 6, 2025 |
| 4 | Insider transaction | Feb 7, 2025 | Feb 6, 2025 |
| 4 | Insider transaction | Feb 7, 2025 | Feb 6, 2025 |
| 4 | Insider transaction | Feb 7, 2025 | Feb 6, 2025 |
| 4 | Insider transaction | Dec 17, 2024 | Dec 16, 2024 |
| 3 | Initial insider ownership | Dec 17, 2024 | Dec 16, 2024 |
| SC 13G | Ownership over 5% (passive) | Nov 7, 2024 | — |
| 10-Q | Quarterly report | Nov 7, 2024 | Sep 30, 2024 |
| 8-K |
Current report
Results of operations
|
Nov 7, 2024 | Nov 7, 2024 |
| SC 13D | Ownership over 5% (active) | Oct 22, 2024 | — |
| SC 13G | Ownership over 5% (passive) | Oct 18, 2024 | — |
| 4 | Insider transaction | Oct 17, 2024 | Oct 15, 2024 |
| 4 | Insider transaction | Oct 17, 2024 | Oct 15, 2024 |
| SC 13D | Ownership over 5% (active) | Oct 17, 2024 | — |
| 4 | Insider transaction | Oct 17, 2024 | Oct 15, 2024 |
| SEC STAFF LETTER | Filing | Oct 16, 2024 | — |
| 4 | Insider transaction | Oct 15, 2024 | Oct 15, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 10, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 10, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 10, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 10, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 10, 2024 |
| 4 | Insider transaction | Oct 15, 2024 | Oct 10, 2024 |
| 8-K |
Current report
Bylaw or fiscal year change
|
Oct 15, 2024 | Oct 10, 2024 |
| S-8 | Employee stock plan registration | Oct 11, 2024 | — |
| 424B4 | Prospectus | Oct 11, 2024 | — |
| EFFECT | Filing | Oct 10, 2024 | — |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| S-1MEF | Filing | Oct 10, 2024 | — |
| 3 | Initial insider ownership | Oct 10, 2024 | Oct 10, 2024 |
| CERT | Filing | Oct 10, 2024 | — |
| 8-A12B | Filing | Oct 8, 2024 | — |
| CORRESP | Letter to the SEC | Oct 8, 2024 | — |
| CORRESP | Letter to the SEC | Oct 8, 2024 | — |
| S-1/A | Amended registration statement | Oct 7, 2024 | — |
| CORRESP | Letter to the SEC | Sep 30, 2024 | — |
| CORRESP | Letter to the SEC | Sep 18, 2024 | — |
| S-1 | Registration statement | Sep 18, 2024 | — |
| UPLOAD | Letter from the SEC | Aug 20, 2024 | — |
| DRSLTR | Filing | Aug 9, 2024 | — |
| DRS/A | Filing | Aug 9, 2024 | — |
| UPLOAD | Letter from the SEC | Jul 25, 2024 | — |
| DRSLTR | Filing | Jul 18, 2024 | — |
| DRS/A | Filing | Jul 18, 2024 | — |
| SEC STAFF LETTER | Filing | Jul 9, 2024 | — |
| UPLOAD | Letter from the SEC | Jul 9, 2024 | — |
| DRS | Filing | Jun 12, 2024 | — |
Showing 134 filings. Main filings leave out insider and ownership forms such as Form 4; choose a type above to see them. Each form opens on SEC.gov. Older filings are on SEC EDGAR.
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Company profile
- Industry
- Pharmaceutical Preparations (SIC 2834)
- Listed as
- UPB (Nasdaq)
- Fiscal year ends
- December 31
- Incorporated in
- DE
- Headquarters
- Waltham, MA
- SEC filer status
- , Emerging growth company
- SEC CIK
- 2022626
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Source: SEC EDGAR filings. This is company-reported data, not investment advice.