As of Jun 30, 2026, Upstream Bio, Inc. had total assets of $281.2 million and total liabilities of $10.2 million. Total assets were down 33.1% from a year earlier. Stockholders' equity was $271.0 million. It held $261.3 million in cash and investments against $954,000 of total debt, net cash of $260.4 million. The current ratio, current assets divided by current liabilities, was 27.99.
USD in millions, except ratios and per-share amounts. The percent under a figure is the change from the year before.
| Line |
FY 2026
Jun 30, 2026
|
FY 2025
Dec 31, 2025
|
FY 2024
Dec 31, 2024
|
|---|---|---|---|
| Assets | |||
| Cash |
79
+74.7%
|
102
-68.8%
|
326
|
| Short-term investments |
182
-47.7%
|
240
+66.0%
|
145
|
| Cash and investments |
261
-33.6%
|
342
-27.4%
|
470
|
| Receivables |
1
-17.6%
|
1
+9.0%
|
1
|
| Total current assets |
280
-33.2%
|
352
-26.6%
|
479
|
| Property and equipment, net |
0
-15.4%
|
1
-4.0%
|
1
|
| Goodwill |
—
|
—
|
0
|
| Total assets |
281
-33.1%
|
354
-26.6%
|
482
|
| Liabilities and equity | |||
| Accounts payable |
2
-9.3%
|
3
-32.5%
|
4
|
| Total current liabilities |
10
-8.6%
|
13
+25.3%
|
11
|
| Total liabilities |
10
-13.3%
|
14
+18.0%
|
12
|
| Stockholders' equity |
271
-33.7%
|
340
-27.7%
|
470
|
| Debt | |||
| Lease liabilities |
1
-38.9%
|
1
-30.8%
|
2
|
| Total debt |
1
-38.9%
|
1
-30.8%
|
2
|
| Net cash |
260
-33.6%
|
340
-27.4%
|
469
|
| Ratios | |||
| Current ratio |
27.99x
|
26.15x
|
44.63x
|
| Debt to equity |
0.00x
|
0.00x
|
0.00x
|
| Return on equity |
-57.76%
|
-42.22%
|
-13.37%
|
| Return on assets |
-55.66%
|
-40.55%
|
-13.04%
|
| Book value per share |
4.95
|
6.26
|
8.77
|
How these figures are calculated
Annual columns are full-year amounts from the annual report (Form 10-K, 20-F, or 40-F). If a company restates a year, the latest filed number is shown. USD in millions, except ratios and per-share amounts. Cash and investments adds short-term and long-term marketable securities to cash. Debt due within a year is the borrowings that are not already in long-term debt. Total debt is those borrowings plus lease liabilities. Net cash is cash and investments minus total debt. Return on equity and return on assets divide the trailing twelve months of net income by the balance on that date. Debt to EBITDA uses the trailing twelve months of EBITDA. The first column is the latest balance sheet when it is newer than the latest fiscal year. More on our methodology.
Company profile
- Industry
- Pharmaceutical Preparations (SIC 2834)
- Listed as
- UPB (Nasdaq)
- Fiscal year ends
- December 31
- Incorporated in
- DE
- Headquarters
- Waltham, MA
- SEC filer status
- , Emerging growth company
- SEC CIK
- 2022626
Other Pharmaceutical Preparations companies
- ELI LILLY & Co LLY
- Johnson & Johnson JNJ
- AbbVie Inc. ABBV
- Merck & Co., Inc. MRK
- Novartis AG NVS
- Astrazeneca PLC AZN
- Abbott Laboratories ABT
- Novo Nordisk A S NVO
Source: SEC EDGAR filings. This is company-reported data, not investment advice.