Spyre Therapeutics, Inc. SEC filings SYRE
Spyre Therapeutics, Inc. has 823 filings in SEC EDGAR's recent list, going back to Mar 24, 2015. Its latest annual report, Form ARS, was filed on Apr 10, 2026 for the period ended Dec 31, 2025. The latest quarterly report (Form 10-Q) was filed on Nov 3, 2026, covering the quarter ended Sep 30, 2026. The most recent current report (Form 8-K) was filed on Nov 3, 2026 (results of operations). The company's fiscal year ends on December 31.
| Form | Description | Filed | Period |
|---|---|---|---|
| SCHEDULE 13D/A | Amended ownership over 5% (active) | Oct 9, 2026 | — |
| 4 | Insider transaction | Oct 2, 2026 | Oct 1, 2026 |
| 4 | Insider transaction | Oct 2, 2026 | Oct 1, 2026 |
| 4 | Insider transaction | Oct 2, 2026 | Sep 30, 2026 |
| 144 | Notice of proposed sale | Oct 1, 2026 | — |
| 144 | Notice of proposed sale | Oct 1, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Oct 1, 2026 | — |
| 144 | Notice of proposed sale | Sep 30, 2026 | — |
| 4 | Insider transaction | Sep 3, 2026 | Sep 1, 2026 |
| 4 | Insider transaction | Sep 3, 2026 | Sep 1, 2026 |
| 4 | Insider transaction | Sep 3, 2026 | Sep 1, 2026 |
| 144 | Notice of proposed sale | Sep 1, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 14, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 14, 2026 | — |
| 4 | Insider transaction | Aug 10, 2026 | Aug 7, 2026 |
| 144 | Notice of proposed sale | Aug 7, 2026 | — |
| 144 | Notice of proposed sale | Aug 7, 2026 | — |
| 4 | Insider transaction | Aug 5, 2026 | Aug 3, 2026 |
| 4 | Insider transaction | Aug 5, 2026 | Aug 3, 2026 |
| 144 | Notice of proposed sale | Aug 3, 2026 | — |
| 4 | Insider transaction | Jul 2, 2026 | Jul 1, 2026 |
| 4 | Insider transaction | Jul 2, 2026 | Jul 1, 2026 |
| 4 | Insider transaction | Jul 2, 2026 | Jul 1, 2026 |
| 144 | Notice of proposed sale | Jul 1, 2026 | — |
| 4 | Insider transaction | Jun 26, 2026 | Jun 25, 2026 |
| 144 | Notice of proposed sale | Jun 25, 2026 | — |
| 144 | Notice of proposed sale | Jun 23, 2026 | — |
| 4 | Insider transaction | Jun 23, 2026 | Jun 23, 2026 |
| SCHEDULE 13D/A | Amended ownership over 5% (active) | Jun 23, 2026 | — |
| 4 | Insider transaction | Jun 23, 2026 | Jun 22, 2026 |
| 144 | Notice of proposed sale | Jun 22, 2026 | — |
| 4 | Insider transaction | Jun 3, 2026 | Jun 3, 2026 |
| 4 | Insider transaction | Jun 3, 2026 | Jun 1, 2026 |
| 4 | Insider transaction | Jun 3, 2026 | Jun 1, 2026 |
| 144 | Notice of proposed sale | Jun 3, 2026 | — |
| 4 | Insider transaction | May 29, 2026 | May 27, 2026 |
| 4 | Insider transaction | May 29, 2026 | May 27, 2026 |
| 4 | Insider transaction | May 29, 2026 | May 27, 2026 |
| 4 | Insider transaction | May 29, 2026 | May 27, 2026 |
| 4 | Insider transaction | May 29, 2026 | May 27, 2026 |
| 4 | Insider transaction | May 29, 2026 | May 27, 2026 |
| 4 | Insider transaction | May 8, 2026 | May 8, 2026 |
| 144 | Notice of proposed sale | May 8, 2026 | — |
| 4 | Insider transaction | May 1, 2026 | May 1, 2026 |
| 4 | Insider transaction | May 1, 2026 | May 1, 2026 |
| 4 | Insider transaction | May 1, 2026 | May 1, 2026 |
| 144 | Notice of proposed sale | May 1, 2026 | — |
| 144 | Notice of proposed sale | May 1, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Apr 22, 2026 | — |
| SCHEDULE 13D/A | Amended ownership over 5% (active) | Apr 20, 2026 | — |
| 4 | Insider transaction | Apr 3, 2026 | Apr 1, 2026 |
| 4 | Insider transaction | Apr 3, 2026 | Apr 1, 2026 |
| 4 | Insider transaction | Apr 3, 2026 | Apr 1, 2026 |
| 144 | Notice of proposed sale | Apr 1, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Mar 27, 2026 | — |
| 4 | Insider transaction | Mar 3, 2026 | Mar 3, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 144 | Notice of proposed sale | Mar 3, 2026 | — |
| 144 | Notice of proposed sale | Mar 2, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 17, 2026 | — |
| 4 | Insider transaction | Feb 4, 2026 | Feb 2, 2026 |
| 4 | Insider transaction | Jan 23, 2026 | Jan 21, 2026 |
| 4 | Insider transaction | Jan 13, 2026 | Jan 9, 2026 |
| 4 | Insider transaction | Jan 13, 2026 | Jan 9, 2026 |
| 4 | Insider transaction | Jan 13, 2026 | Jan 9, 2026 |
| 4 | Insider transaction | Jan 13, 2026 | Jan 9, 2026 |
| 4 | Insider transaction | Jan 6, 2026 | Jan 2, 2026 |
| 4 | Insider transaction | Dec 3, 2025 | Dec 1, 2025 |
| 4 | Insider transaction | Nov 5, 2025 | Nov 3, 2025 |
| 144 | Notice of proposed sale | Nov 3, 2025 | — |
| SCHEDULE 13D/A | Amended ownership over 5% (active) | Oct 17, 2025 | — |
| 4 | Insider transaction | Sep 3, 2025 | Sep 2, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Jul 29, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Jul 16, 2025 | — |
| 4 | Insider transaction | Jun 2, 2025 | May 29, 2025 |
| 4 | Insider transaction | Jun 2, 2025 | May 29, 2025 |
| 4 | Insider transaction | Jun 2, 2025 | May 29, 2025 |
| 4 | Insider transaction | Jun 2, 2025 | May 29, 2025 |
| 4 | Insider transaction | Jun 2, 2025 | May 29, 2025 |
| 4 | Insider transaction | Jun 2, 2025 | May 29, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | May 1, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 14, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 14, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 14, 2025 | — |
| 4 | Insider transaction | Jan 17, 2025 | Jan 15, 2025 |
| 4 | Insider transaction | Jan 17, 2025 | Jan 15, 2025 |
| 4 | Insider transaction | Jan 17, 2025 | Jan 15, 2025 |
| 4 | Insider transaction | Jan 17, 2025 | Jan 15, 2025 |
| 4 | Insider transaction | Jan 14, 2025 | Jan 10, 2025 |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 12, 2024 | — |
| 4 | Insider transaction | Nov 8, 2024 | Nov 6, 2024 |
| SC 13G | Ownership over 5% (passive) | Nov 8, 2024 | — |
| 4 | Insider transaction | Oct 28, 2024 | Oct 25, 2024 |
| 144 | Notice of proposed sale | Oct 25, 2024 | — |
| SC 13G | Ownership over 5% (passive) | Oct 23, 2024 | — |
| SC 13G | Ownership over 5% (passive) | Oct 22, 2024 | — |
| 4 | Insider transaction | Oct 1, 2024 | Oct 1, 2024 |
| 3 | Initial insider ownership | Oct 1, 2024 | Oct 1, 2024 |
| 4 | Insider transaction | Sep 5, 2024 | Sep 3, 2024 |
| SC 13G/A | Amended ownership over 5% (passive) | Jun 10, 2024 | — |
| 4 | Insider transaction | May 16, 2024 | May 14, 2024 |
| 4 | Insider transaction | May 16, 2024 | May 14, 2024 |
| 4 | Insider transaction | May 16, 2024 | May 14, 2024 |
| 4 | Insider transaction | May 16, 2024 | May 14, 2024 |
| 4 | Insider transaction | May 16, 2024 | May 14, 2024 |
| 3 | Initial insider ownership | May 16, 2024 | May 14, 2024 |
| 4 | Insider transaction | Apr 25, 2024 | Apr 25, 2024 |
| SC 13D/A | Amended ownership over 5% (active) | Apr 25, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Apr 23, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Mar 11, 2024 | — |
| 4 | Insider transaction | Feb 20, 2024 | Feb 15, 2024 |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G | Ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G | Ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 13, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 13, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 13, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 13, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 12, 2024 | — |
| SC 13G | Ownership over 5% (passive) | Feb 9, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 8, 2024 | — |
| 4 | Insider transaction | Feb 5, 2024 | Feb 1, 2024 |
| 3 | Initial insider ownership | Feb 5, 2024 | Feb 1, 2024 |
| 4 | Insider transaction | Feb 2, 2024 | Feb 1, 2024 |
| 4 | Insider transaction | Feb 2, 2024 | Feb 1, 2024 |
| 4 | Insider transaction | Feb 2, 2024 | Feb 1, 2024 |
| SC 13D/A | Amended ownership over 5% (active) | Dec 29, 2023 | — |
| 4 | Insider transaction | Dec 29, 2023 | Dec 29, 2023 |
| 4 | Insider transaction | Dec 22, 2023 | Dec 22, 2023 |
| SC 13G | Ownership over 5% (passive) | Dec 13, 2023 | — |
| 4 | Insider transaction | Dec 11, 2023 | Dec 7, 2023 |
| SC 13D/A | Amended ownership over 5% (active) | Dec 11, 2023 | — |
| 4/A | Filing | Dec 8, 2023 | Nov 22, 2023 |
| 3/A | Filing | Dec 8, 2023 | Nov 22, 2023 |
| SC 13G | Ownership over 5% (passive) | Dec 1, 2023 | — |
| SC 13D/A | Amended ownership over 5% (active) | Nov 29, 2023 | — |
| 4 | Insider transaction | Nov 28, 2023 | Nov 24, 2023 |
| 4 | Insider transaction | Nov 27, 2023 | Nov 22, 2023 |
| 4 | Insider transaction | Nov 27, 2023 | Nov 22, 2023 |
| 3 | Initial insider ownership | Nov 27, 2023 | Nov 22, 2023 |
| 3 | Initial insider ownership | Nov 27, 2023 | Nov 22, 2023 |
| 4 | Insider transaction | Nov 27, 2023 | Nov 22, 2023 |
| SC 13G | Ownership over 5% (passive) | Nov 14, 2023 | — |
| 4 | Insider transaction | Sep 5, 2023 | Sep 1, 2023 |
| 3 | Initial insider ownership | Sep 5, 2023 | Sep 1, 2023 |
| 4 | Insider transaction | Sep 5, 2023 | Sep 1, 2023 |
| 3 | Initial insider ownership | Sep 5, 2023 | Sep 1, 2023 |
| SC 13G | Ownership over 5% (passive) | Jul 28, 2023 | — |
| SC 13G | Ownership over 5% (passive) | Jul 18, 2023 | — |
| SC 13G | Ownership over 5% (passive) | Jul 10, 2023 | — |
| SC 13G | Ownership over 5% (passive) | Jul 3, 2023 | — |
| 3 | Initial insider ownership | Jun 30, 2023 | Jun 22, 2023 |
| SC 13D | Ownership over 5% (active) | Jun 30, 2023 | — |
| 3 | Initial insider ownership | Jun 30, 2023 | Jun 22, 2023 |
| 3 | Initial insider ownership | Jun 30, 2023 | Jun 22, 2023 |
| 4 | Insider transaction | Jun 30, 2023 | Jun 22, 2023 |
| 4 | Insider transaction | Jun 30, 2023 | Jun 22, 2023 |
| 4 | Insider transaction | Jun 30, 2023 | Jun 22, 2023 |
| 4 | Insider transaction | Jun 30, 2023 | Jun 22, 2023 |
| 4 | Insider transaction | Jun 30, 2023 | Jun 22, 2023 |
| SC 13G | Ownership over 5% (passive) | Jun 30, 2023 | — |
| SC 13G | Ownership over 5% (passive) | Jun 30, 2023 | — |
| 4 | Insider transaction | Feb 24, 2023 | Feb 23, 2023 |
| 4 | Insider transaction | Feb 24, 2023 | Feb 23, 2023 |
| 4 | Insider transaction | Feb 24, 2023 | Feb 23, 2023 |
| 4 | Insider transaction | Feb 24, 2023 | Feb 23, 2023 |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2023 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2023 | — |
| SC 13G | Ownership over 5% (passive) | Feb 14, 2023 | — |
| SC 13G | Ownership over 5% (passive) | Feb 14, 2023 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2023 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 13, 2023 | — |
| SC 13G | Ownership over 5% (passive) | Feb 3, 2023 | — |
| 4 | Insider transaction | Jan 27, 2023 | Nov 14, 2022 |
| 3 | Initial insider ownership | Jan 27, 2023 | Nov 14, 2022 |
| SC 13G/A | Amended ownership over 5% (passive) | Jan 10, 2023 | — |
| 4 | Insider transaction | Dec 1, 2022 | Nov 29, 2022 |
| 3 | Initial insider ownership | Dec 1, 2022 | Nov 29, 2022 |
| SC 13G | Ownership over 5% (passive) | Dec 1, 2022 | — |
| 4 | Insider transaction | Aug 25, 2022 | Aug 23, 2022 |
| 3 | Initial insider ownership | Aug 25, 2022 | Aug 23, 2022 |
| 4 | Insider transaction | Aug 25, 2022 | Aug 25, 2022 |
| 4 | Insider transaction | Aug 25, 2022 | Aug 23, 2022 |
| 4 | Insider transaction | Aug 25, 2022 | Aug 23, 2022 |
| 4 | Insider transaction | Aug 25, 2022 | Aug 23, 2022 |
| 4 | Insider transaction | Jun 10, 2022 | Jun 8, 2022 |
| 4 | Insider transaction | Jun 10, 2022 | Jun 7, 2022 |
Showing 200 filings, the most recent 200. Main filings leave out insider and ownership forms such as Form 4; choose a type above to see them. Each form opens on SEC.gov. Older filings are on SEC EDGAR.
New to this? Read What Are SEC Filings? 10-K, 10-Q, 8-K and Other Forms Explained.
Company profile
- Industry
- Pharmaceutical Preparations (SIC 2834)
- Listed as
- SYRE (Nasdaq)
- Fiscal year ends
- December 31
- Incorporated in
- DE
- Headquarters
- Waltham, MA
- SEC filer status
- Large accelerated filer
- SEC CIK
- 1636282
- Former names
- Aeglea BioTherapeutics, Inc. (until Nov 24, 2023)
Other Pharmaceutical Preparations companies
- ELI LILLY & Co LLY
- Johnson & Johnson JNJ
- AbbVie Inc. ABBV
- Merck & Co., Inc. MRK
- Novartis AG NVS
- Astrazeneca PLC AZN
- Abbott Laboratories ABT
- Novo Nordisk A S NVO
Source: SEC EDGAR filings. This is company-reported data, not investment advice.