Spyre Therapeutics, Inc. SEC filings SYRE
Spyre Therapeutics, Inc. has 823 filings in SEC EDGAR's recent list, going back to Mar 24, 2015. Its latest annual report, Form ARS, was filed on Apr 10, 2026 for the period ended Dec 31, 2025. The latest quarterly report (Form 10-Q) was filed on Nov 3, 2026, covering the quarter ended Sep 30, 2026. The most recent current report (Form 8-K) was filed on Nov 3, 2026 (results of operations). The company's fiscal year ends on December 31.
| Form | Description | Filed | Period |
|---|---|---|---|
| 8-K |
Current report
Results of operations
|
Nov 3, 2026 | Nov 3, 2026 |
| 10-Q | Quarterly report | Nov 3, 2026 | Sep 30, 2026 |
| SCHEDULE 13D/A | Amended ownership over 5% (active) | Oct 9, 2026 | — |
| 8-K |
Current report
Material agreement
|
Oct 7, 2026 | Oct 5, 2026 |
| 424B5 | Prospectus supplement | Oct 6, 2026 | — |
| 424B5 | Prospectus supplement | Oct 5, 2026 | — |
| 4 | Insider transaction | Oct 2, 2026 | Oct 1, 2026 |
| 4 | Insider transaction | Oct 2, 2026 | Oct 1, 2026 |
| 4 | Insider transaction | Oct 2, 2026 | Sep 30, 2026 |
| 144 | Notice of proposed sale | Oct 1, 2026 | — |
| 144 | Notice of proposed sale | Oct 1, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Oct 1, 2026 | — |
| 144 | Notice of proposed sale | Sep 30, 2026 | — |
| 8-K |
Current report
Regulation FD disclosure, Other events
|
Sep 8, 2026 | Sep 8, 2026 |
| 4 | Insider transaction | Sep 3, 2026 | Sep 1, 2026 |
| 4 | Insider transaction | Sep 3, 2026 | Sep 1, 2026 |
| 4 | Insider transaction | Sep 3, 2026 | Sep 1, 2026 |
| 144 | Notice of proposed sale | Sep 1, 2026 | — |
| 8-K |
Current report
Regulation FD disclosure, Other events
|
Aug 25, 2026 | Aug 25, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 14, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 14, 2026 | — |
| 4 | Insider transaction | Aug 10, 2026 | Aug 7, 2026 |
| 144 | Notice of proposed sale | Aug 7, 2026 | — |
| 144 | Notice of proposed sale | Aug 7, 2026 | — |
| 4 | Insider transaction | Aug 5, 2026 | Aug 3, 2026 |
| 4 | Insider transaction | Aug 5, 2026 | Aug 3, 2026 |
| 8-K |
Current report
Results of operations
|
Aug 4, 2026 | Aug 4, 2026 |
| 10-Q | Quarterly report | Aug 4, 2026 | Jun 30, 2026 |
| 144 | Notice of proposed sale | Aug 3, 2026 | — |
| 4 | Insider transaction | Jul 2, 2026 | Jul 1, 2026 |
| 4 | Insider transaction | Jul 2, 2026 | Jul 1, 2026 |
| 4 | Insider transaction | Jul 2, 2026 | Jul 1, 2026 |
| 144 | Notice of proposed sale | Jul 1, 2026 | — |
| 4 | Insider transaction | Jun 26, 2026 | Jun 25, 2026 |
| S-3ASR | Automatic shelf registration | Jun 26, 2026 | — |
| 144 | Notice of proposed sale | Jun 25, 2026 | — |
| 144 | Notice of proposed sale | Jun 23, 2026 | — |
| 4 | Insider transaction | Jun 23, 2026 | Jun 23, 2026 |
| SCHEDULE 13D/A | Amended ownership over 5% (active) | Jun 23, 2026 | — |
| 4 | Insider transaction | Jun 23, 2026 | Jun 22, 2026 |
| 144 | Notice of proposed sale | Jun 22, 2026 | — |
| 8-K |
Current report
Regulation FD disclosure, Other events
|
Jun 15, 2026 | Jun 15, 2026 |
| 4 | Insider transaction | Jun 3, 2026 | Jun 3, 2026 |
| 4 | Insider transaction | Jun 3, 2026 | Jun 1, 2026 |
| 4 | Insider transaction | Jun 3, 2026 | Jun 1, 2026 |
| 144 | Notice of proposed sale | Jun 3, 2026 | — |
| 8-K |
Current report
Other events
|
Jun 1, 2026 | May 29, 2026 |
| 4 | Insider transaction | May 29, 2026 | May 27, 2026 |
| 4 | Insider transaction | May 29, 2026 | May 27, 2026 |
| 4 | Insider transaction | May 29, 2026 | May 27, 2026 |
| 4 | Insider transaction | May 29, 2026 | May 27, 2026 |
| 4 | Insider transaction | May 29, 2026 | May 27, 2026 |
| 4 | Insider transaction | May 29, 2026 | May 27, 2026 |
| 8-K |
Current report
Officer or director change, Shareholder vote results
|
May 29, 2026 | May 27, 2026 |
| 4 | Insider transaction | May 8, 2026 | May 8, 2026 |
| 144 | Notice of proposed sale | May 8, 2026 | — |
| 8-K |
Current report
Results of operations
|
May 5, 2026 | May 5, 2026 |
| 10-Q | Quarterly report | May 5, 2026 | Mar 31, 2026 |
| 4 | Insider transaction | May 1, 2026 | May 1, 2026 |
| 4 | Insider transaction | May 1, 2026 | May 1, 2026 |
| 4 | Insider transaction | May 1, 2026 | May 1, 2026 |
| 144 | Notice of proposed sale | May 1, 2026 | — |
| 144 | Notice of proposed sale | May 1, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Apr 22, 2026 | — |
| SCHEDULE 13D/A | Amended ownership over 5% (active) | Apr 20, 2026 | — |
| 8-K |
Current report
Material agreement
|
Apr 16, 2026 | Apr 14, 2026 |
| 424B5 | Prospectus supplement | Apr 16, 2026 | — |
| 424B5 | Prospectus supplement | Apr 13, 2026 | — |
| 8-K |
Current report
Results of operations, Other events
|
Apr 13, 2026 | Apr 13, 2026 |
| 8-K |
Current report
Regulation FD disclosure, Other events
|
Apr 13, 2026 | Apr 13, 2026 |
| ARS | Annual report to shareholders | Apr 10, 2026 | Dec 31, 2025 |
| DEFA14A | Additional proxy material | Apr 10, 2026 | — |
| DEF 14A | Proxy statement | Apr 10, 2026 | May 27, 2026 |
| 4 | Insider transaction | Apr 3, 2026 | Apr 1, 2026 |
| 4 | Insider transaction | Apr 3, 2026 | Apr 1, 2026 |
| 4 | Insider transaction | Apr 3, 2026 | Apr 1, 2026 |
| 144 | Notice of proposed sale | Apr 1, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Mar 27, 2026 | — |
| EFFECT | Filing | Mar 4, 2026 | — |
| 4 | Insider transaction | Mar 3, 2026 | Mar 3, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 144 | Notice of proposed sale | Mar 3, 2026 | — |
| 144 | Notice of proposed sale | Mar 2, 2026 | — |
| EFFECT | Filing | Feb 27, 2026 | — |
| POS AM | Filing | Feb 27, 2026 | — |
| CORRESP | Letter to the SEC | Feb 25, 2026 | — |
| UPLOAD | Letter from the SEC | Feb 25, 2026 | — |
| S-3 | Shelf registration | Feb 19, 2026 | — |
| S-8 | Employee stock plan registration | Feb 19, 2026 | — |
| 8-K |
Current report
Results of operations
|
Feb 19, 2026 | Feb 19, 2026 |
| 10-K | Annual report | Feb 19, 2026 | Dec 31, 2025 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 17, 2026 | — |
| 4 | Insider transaction | Feb 4, 2026 | Feb 2, 2026 |
| 4 | Insider transaction | Jan 23, 2026 | Jan 21, 2026 |
| 4 | Insider transaction | Jan 13, 2026 | Jan 9, 2026 |
| 4 | Insider transaction | Jan 13, 2026 | Jan 9, 2026 |
| 4 | Insider transaction | Jan 13, 2026 | Jan 9, 2026 |
| 4 | Insider transaction | Jan 13, 2026 | Jan 9, 2026 |
| 8-K |
Current report
Regulation FD disclosure
|
Jan 12, 2026 | Jan 12, 2026 |
| 4 | Insider transaction | Jan 6, 2026 | Jan 2, 2026 |
| 4 | Insider transaction | Dec 3, 2025 | Dec 1, 2025 |
| 4 | Insider transaction | Nov 5, 2025 | Nov 3, 2025 |
| 8-K |
Current report
Results of operations, Regulation FD disclosure, Other events
|
Nov 4, 2025 | Nov 4, 2025 |
| 10-Q | Quarterly report | Nov 4, 2025 | Sep 30, 2025 |
| 144 | Notice of proposed sale | Nov 3, 2025 | — |
| SCHEDULE 13D/A | Amended ownership over 5% (active) | Oct 17, 2025 | — |
| 8-K |
Current report
Material agreement
|
Oct 15, 2025 | Oct 13, 2025 |
| 424B5 | Prospectus supplement | Oct 14, 2025 | — |
| 424B5 | Prospectus supplement | Oct 14, 2025 | — |
| 8-K |
Current report
Results of operations
|
Oct 14, 2025 | Oct 14, 2025 |
| 4 | Insider transaction | Sep 3, 2025 | Sep 2, 2025 |
| S-8 | Employee stock plan registration | Aug 5, 2025 | — |
| 8-K |
Current report
Results of operations
|
Aug 5, 2025 | Aug 5, 2025 |
| 10-Q | Quarterly report | Aug 5, 2025 | Jun 30, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Jul 29, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Jul 16, 2025 | — |
| 8-K |
Current report
Regulation FD disclosure, Other events
|
Jun 17, 2025 | Jun 17, 2025 |
| 4 | Insider transaction | Jun 2, 2025 | May 29, 2025 |
| 4 | Insider transaction | Jun 2, 2025 | May 29, 2025 |
| 4 | Insider transaction | Jun 2, 2025 | May 29, 2025 |
| 4 | Insider transaction | Jun 2, 2025 | May 29, 2025 |
| 4 | Insider transaction | Jun 2, 2025 | May 29, 2025 |
| 4 | Insider transaction | Jun 2, 2025 | May 29, 2025 |
| 8-K |
Current report
Shareholder vote results
|
Jun 2, 2025 | May 29, 2025 |
| UPLOAD | Letter from the SEC | Jun 2, 2025 | — |
| CORRESP | Letter to the SEC | May 21, 2025 | — |
| UPLOAD | Letter from the SEC | May 9, 2025 | — |
| 8-K |
Current report
Results of operations
|
May 8, 2025 | May 8, 2025 |
| 10-Q | Quarterly report | May 8, 2025 | Mar 31, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | May 1, 2025 | — |
| ARS | Annual report to shareholders | Apr 14, 2025 | Dec 31, 2024 |
| DEFA14A | Additional proxy material | Apr 14, 2025 | — |
| DEF 14A | Proxy statement | Apr 14, 2025 | May 29, 2025 |
| EFFECT | Filing | Mar 13, 2025 | — |
| EFFECT | Filing | Mar 7, 2025 | — |
| POS AM | Filing | Mar 7, 2025 | — |
| 8-K |
Current report
Auditor change
|
Mar 6, 2025 | Feb 28, 2025 |
| CORRESP | Letter to the SEC | Mar 5, 2025 | — |
| UPLOAD | Letter from the SEC | Mar 4, 2025 | — |
| S-3 | Shelf registration | Feb 27, 2025 | — |
| S-8 | Employee stock plan registration | Feb 27, 2025 | — |
| 8-K |
Current report
Results of operations
|
Feb 27, 2025 | Feb 27, 2025 |
| 10-K | Annual report | Feb 27, 2025 | Dec 31, 2024 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 14, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 14, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 14, 2025 | — |
| 4 | Insider transaction | Jan 17, 2025 | Jan 15, 2025 |
| 4 | Insider transaction | Jan 17, 2025 | Jan 15, 2025 |
| 4 | Insider transaction | Jan 17, 2025 | Jan 15, 2025 |
| 4 | Insider transaction | Jan 17, 2025 | Jan 15, 2025 |
| 4 | Insider transaction | Jan 14, 2025 | Jan 10, 2025 |
| 8-K |
Current report
Results of operations, Other events
|
Jan 13, 2025 | Jan 13, 2025 |
| 8-K |
Current report
Material agreement
|
Nov 19, 2024 | Nov 18, 2024 |
| 424B5 | Prospectus supplement | Nov 19, 2024 | — |
| 424B5 | Prospectus supplement | Nov 18, 2024 | — |
| 10-Q/A | Amended quarterly report | Nov 18, 2024 | Sep 30, 2024 |
| 10-Q/A | Amended quarterly report | Nov 18, 2024 | Jun 30, 2024 |
| 10-Q/A | Amended quarterly report | Nov 18, 2024 | Mar 31, 2024 |
| 10-K/A | Amended annual report | Nov 18, 2024 | Dec 31, 2023 |
| 8-K |
Current report
Restatement, Other events
|
Nov 18, 2024 | Nov 18, 2024 |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 12, 2024 | — |
| 8-K |
Current report
Regulation FD disclosure, Other events
|
Nov 12, 2024 | Nov 12, 2024 |
| 4 | Insider transaction | Nov 8, 2024 | Nov 6, 2024 |
| SC 13G | Ownership over 5% (passive) | Nov 8, 2024 | — |
| S-8 | Employee stock plan registration | Nov 7, 2024 | — |
| 8-K |
Current report
Results of operations
|
Nov 7, 2024 | Nov 7, 2024 |
| 10-Q | Quarterly report | Nov 7, 2024 | Sep 30, 2024 |
| 4 | Insider transaction | Oct 28, 2024 | Oct 25, 2024 |
| 144 | Notice of proposed sale | Oct 25, 2024 | — |
| SC 13G | Ownership over 5% (passive) | Oct 23, 2024 | — |
| SC 13G | Ownership over 5% (passive) | Oct 22, 2024 | — |
| 8-K |
Current report
Material agreement, Regulation FD disclosure, Other events
|
Oct 15, 2024 | Oct 11, 2024 |
| EFFECT | Filing | Oct 2, 2024 | — |
| 4 | Insider transaction | Oct 1, 2024 | Oct 1, 2024 |
| 3 | Initial insider ownership | Oct 1, 2024 | Oct 1, 2024 |
| CORRESP | Letter to the SEC | Sep 30, 2024 | — |
| UPLOAD | Letter from the SEC | Sep 26, 2024 | — |
| S-3 | Shelf registration | Sep 20, 2024 | — |
| EFFECT | Filing | Sep 18, 2024 | — |
| CORRESP | Letter to the SEC | Sep 13, 2024 | — |
| UPLOAD | Letter from the SEC | Sep 12, 2024 | — |
| S-3 | Shelf registration | Sep 6, 2024 | — |
| 4 | Insider transaction | Sep 5, 2024 | Sep 3, 2024 |
| 424B3 | Prospectus | Aug 8, 2024 | — |
| 8-K/A |
Amended current report
Other events
|
Aug 8, 2024 | Aug 7, 2024 |
| 8-K |
Current report
Results of operations
|
Aug 7, 2024 | Aug 7, 2024 |
| 10-Q | Quarterly report | Aug 7, 2024 | Jun 30, 2024 |
| SC 13G/A | Amended ownership over 5% (passive) | Jun 10, 2024 | — |
| 8-K |
Current report
Regulation FD disclosure
|
May 30, 2024 | May 30, 2024 |
| 4 | Insider transaction | May 16, 2024 | May 14, 2024 |
| 4 | Insider transaction | May 16, 2024 | May 14, 2024 |
| 4 | Insider transaction | May 16, 2024 | May 14, 2024 |
| 4 | Insider transaction | May 16, 2024 | May 14, 2024 |
| 4 | Insider transaction | May 16, 2024 | May 14, 2024 |
| 3 | Initial insider ownership | May 16, 2024 | May 14, 2024 |
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Company profile
- Industry
- Pharmaceutical Preparations (SIC 2834)
- Listed as
- SYRE (Nasdaq)
- Fiscal year ends
- December 31
- Incorporated in
- DE
- Headquarters
- Waltham, MA
- SEC filer status
- Large accelerated filer
- SEC CIK
- 1636282
- Former names
- Aeglea BioTherapeutics, Inc. (until Nov 24, 2023)
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Source: SEC EDGAR filings. This is company-reported data, not investment advice.