In fiscal 2025, which ended Dec 31, 2025, Septerna, Inc. generated $110.2 million of cash from operations, up 263.3% from the year before. It spent $518,000 on capital expenditures. That left free cash flow of $109.7 million.
USD in millions, except per-share amounts and ratios. The percent under a figure is the change from the year before.
| Line |
FY 2026
Jun 30, 2026
|
FY 2025
Dec 31, 2025
|
FY 2024
Dec 31, 2024
|
|---|---|---|---|
| Operating | |||
| Depreciation and amortization |
2
|
2
+14.3%
|
1
|
| Stock-based compensation |
16
|
8
+168.9%
|
3
|
| Operating cash flow |
106
|
110
+263.3%
|
-67
|
| Investing | |||
| Capital expenditures |
1
|
1
-75.4%
|
2
|
| Investing cash flow |
-229
|
-229
-42.8%
|
-161
|
| Financing | |||
| Financing cash flow |
18
|
2
-99.6%
|
378
|
| Change in cash | |||
| Net change in cash |
-105
|
-117
-178.5%
|
150
|
| Free cash flow |
105
|
110
+257.6%
|
-70
|
| Per share | |||
| Free cash flow per share |
2.35
|
2.48
+135.2%
|
-7.03
|
| Ratios | |||
| Free cash flow margin |
106.29%
|
238.67%
|
-6,471.91%
|
| Capital expenditures to revenue |
0.92%
|
1.13%
|
195.63%
|
| Stock-based compensation to revenue |
16.46%
|
18.45%
|
293.21%
|
How these figures are calculated
Annual columns are full-year amounts from the annual report (Form 10-K, 20-F, or 40-F). If a company restates a year, the latest filed number is shown. USD in millions, except per-share amounts and ratios. Capital expenditures, debt repaid, dividends, and buybacks are positive amounts. Investing and financing cash flow keep the filing sign, so an outflow is negative. Free cash flow is operating cash flow minus capital expenditures. The first column is the trailing twelve months through the latest quarter. Returned to shareholders is dividends plus buybacks. Free cash flow margin, capital expenditures, and stock-based compensation are divided by revenue. Cash conversion is operating cash flow divided by net income. More on our methodology.
Company profile
- Industry
- Pharmaceutical Preparations (SIC 2834)
- Listed as
- SEPN (Nasdaq)
- Fiscal year ends
- December 31
- Incorporated in
- DE
- Headquarters
- South San Francisco, CA
- SEC filer status
- , Emerging growth company
- SEC CIK
- 1984086
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Source: SEC EDGAR filings. This is company-reported data, not investment advice.