FY2025 · ended Dec 31, 2025 · Revenue $45.95M, +4174.5% YoY · Filed Mar 9, 2026
Septerna, Inc. (SEPN) files with the SEC under industry code 2834, Pharmaceutical Preparations. In fiscal 2025, which ended Dec 31, 2025, it reported revenue of $46.0 million and a net loss of $48.9 million. Free cash flow was $109.7 million. As of Jun 30, 2026 it held $516.5 million in cash and investments and $22.5 million in total debt.
Revenue (TTM)
$98.88M
Net income (TTM)
$-24.24M
Operating cash flow (TTM)
$106.01M
Free cash flow (TTM)
$105.10M
EPS (TTM)
$-0.54
Dividend per share
None
Shares outstanding
44.91M
+1.0% vs prior year
Net cash
$493.97M
as of Jun 30, 2026
Operating margin
-44.0%
FY 2026
Company profile
- Industry
- Pharmaceutical Preparations (SIC 2834)
- Listed as
- SEPN (Nasdaq)
- Fiscal year ends
- December 31
- Incorporated in
- DE
- Headquarters
- South San Francisco, CA
- SEC filer status
- , Emerging growth company
- SEC CIK
- 1984086
Other Pharmaceutical Preparations companies
- ELI LILLY & Co LLY
- Johnson & Johnson JNJ
- AbbVie Inc. ABBV
- Merck & Co., Inc. MRK
- Novartis AG NVS
- Astrazeneca PLC AZN
- Abbott Laboratories ABT
- Novo Nordisk A S NVO
Key figures
Fiscal-year totals from the annual reports. Balance sheet lines are as of each year end.
| Line | FY 2025 Dec 31, 2025 |
FY 2024 Dec 31, 2024 |
|---|---|---|
| Revenue | $46.0M | $1.1M |
| Operating income | -$68.3M | -$80.8M |
| Net income | -$48.9M | -$71.8M |
| Diluted EPS | -$1.10 | -$7.26 |
| Operating cash flow | $110.2M | -$67.5M |
| Free cash flow | $109.7M | -$69.6M |
| Total assets | $596.2M | $456.6M |
| Total liabilities | $214.3M | $36.5M |
| Stockholders' equity | $381.9M | $420.0M |
| Cash and investments | $548.7M | $420.8M |
| Total debt | $23.6M | $25.5M |
Recent SEC filings
| Form | Description | Filed | Period |
|---|---|---|---|
| 8-K |
Current report
Regulation FD disclosure
|
Nov 4, 2026 | Nov 4, 2026 |
| 8-K |
Current report
Regulation FD disclosure, Other events
|
Aug 25, 2026 | Aug 22, 2026 |
| 10-Q | Quarterly report | Aug 10, 2026 | Jun 30, 2026 |
| 8-K |
Current report
Results of operations
|
Aug 10, 2026 | Aug 10, 2026 |
| 8-K |
Current report
Shareholder vote results
|
Jun 30, 2026 | Jun 26, 2026 |
| 10-Q | Quarterly report | May 11, 2026 | Mar 31, 2026 |
All 170 Septerna, Inc. SEC filings
Source: SEC EDGAR filings. This is company-reported data, not investment advice.