Karyopharm Therapeutics Inc. SEC filings KPTI
Karyopharm Therapeutics Inc. has 1,001 filings in SEC EDGAR's recent list, going back to Apr 2, 2015. Its latest annual report, Form ARS, was filed on Apr 13, 2026 for the period ended Dec 31, 2025. The latest quarterly report (Form 10-Q) was filed on Aug 13, 2026, covering the quarter ended Jun 30, 2026. The most recent current report (Form 8-K) was filed on Nov 5, 2026 (listing notice). The company's fiscal year ends on December 31.
| Form | Description | Filed | Period |
|---|---|---|---|
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Oct 28, 2026 | — |
| 4 | Insider transaction | Oct 19, 2026 | Oct 16, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Oct 8, 2026 | — |
| 4 | Insider transaction | Oct 2, 2026 | Oct 1, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Sep 25, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Sep 25, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Sep 4, 2026 | — |
| 4 | Insider transaction | Sep 2, 2026 | Sep 1, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 14, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 14, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 12, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 11, 2026 | — |
| 4 | Insider transaction | Jul 30, 2026 | Jul 28, 2026 |
| SCHEDULE 13G | Ownership over 5% (passive) | Jul 28, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Jun 5, 2026 | — |
| 4 | Insider transaction | May 26, 2026 | May 21, 2026 |
| 4 | Insider transaction | May 26, 2026 | May 21, 2026 |
| 4 | Insider transaction | May 26, 2026 | May 21, 2026 |
| 4 | Insider transaction | May 26, 2026 | May 21, 2026 |
| 4 | Insider transaction | May 26, 2026 | May 21, 2026 |
| 4 | Insider transaction | May 26, 2026 | May 21, 2026 |
| SCHEDULE 13G | Ownership over 5% (passive) | May 15, 2026 | — |
| 4 | Insider transaction | May 15, 2026 | May 13, 2026 |
| 4 | Insider transaction | May 15, 2026 | May 13, 2026 |
| 4 | Insider transaction | May 15, 2026 | May 13, 2026 |
| 4 | Insider transaction | May 15, 2026 | May 13, 2026 |
| 4 | Insider transaction | May 15, 2026 | May 13, 2026 |
| 4 | Insider transaction | May 15, 2026 | May 13, 2026 |
| SCHEDULE 13G | Ownership over 5% (passive) | May 15, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | May 14, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | May 13, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | May 12, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | May 11, 2026 | — |
| 4 | Insider transaction | Apr 22, 2026 | Apr 21, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Apr 13, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Apr 2, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Apr 2, 2026 | — |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 4 | Insider transaction | Feb 19, 2026 | Feb 17, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 17, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 12, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Feb 10, 2026 | — |
| 4 | Insider transaction | Feb 9, 2026 | Feb 5, 2026 |
| 4 | Insider transaction | Feb 4, 2026 | Feb 3, 2026 |
| 4 | Insider transaction | Feb 3, 2026 | Jan 31, 2026 |
| 4 | Insider transaction | Feb 3, 2026 | Jan 31, 2026 |
| 4 | Insider transaction | Feb 3, 2026 | Jan 31, 2026 |
| 4 | Insider transaction | Feb 3, 2026 | Jan 31, 2026 |
| 4 | Insider transaction | Feb 3, 2026 | Jan 31, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Jan 29, 2026 | — |
| 4 | Insider transaction | Jan 29, 2026 | Jan 27, 2026 |
| 4 | Insider transaction | Jan 22, 2026 | Jan 21, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Nov 14, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Nov 7, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Nov 3, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Oct 30, 2025 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Oct 17, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Oct 17, 2025 | — |
| 4 | Insider transaction | Oct 16, 2025 | Oct 15, 2025 |
| 4 | Insider transaction | Oct 16, 2025 | Oct 15, 2025 |
| 4 | Insider transaction | Oct 16, 2025 | Oct 15, 2025 |
| 4 | Insider transaction | Oct 16, 2025 | Oct 15, 2025 |
| 4 | Insider transaction | Oct 16, 2025 | Oct 15, 2025 |
| 4 | Insider transaction | Oct 16, 2025 | Oct 15, 2025 |
| 4 | Insider transaction | Oct 3, 2025 | Oct 1, 2025 |
| 4 | Insider transaction | Sep 16, 2025 | Sep 12, 2025 |
| 4 | Insider transaction | Sep 16, 2025 | Sep 12, 2025 |
| 4 | Insider transaction | Sep 16, 2025 | Sep 12, 2025 |
| 4 | Insider transaction | Sep 16, 2025 | Sep 12, 2025 |
| 4 | Insider transaction | Sep 16, 2025 | Sep 12, 2025 |
| 4 | Insider transaction | Sep 16, 2025 | Sep 12, 2025 |
| 4 | Insider transaction | Sep 4, 2025 | Sep 3, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Aug 14, 2025 | — |
| 4 | Insider transaction | Jul 30, 2025 | Jul 29, 2025 |
| 4 | Insider transaction | Jul 23, 2025 | Jul 22, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Jul 16, 2025 | — |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 7, 2025 | May 6, 2025 |
| 4 | Insider transaction | Apr 24, 2025 | Apr 23, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Apr 10, 2025 | — |
| 4 | Insider transaction | Apr 7, 2025 | Apr 4, 2025 |
| 4 | Insider transaction | Mar 6, 2025 | Mar 4, 2025 |
| 4 | Insider transaction | Mar 6, 2025 | Mar 4, 2025 |
| 4 | Insider transaction | Mar 6, 2025 | Mar 4, 2025 |
| 4 | Insider transaction | Mar 6, 2025 | Mar 4, 2025 |
| 4 | Insider transaction | Mar 6, 2025 | Mar 4, 2025 |
| 4 | Insider transaction | Mar 6, 2025 | Mar 4, 2025 |
| 4 | Insider transaction | Mar 4, 2025 | Feb 28, 2025 |
| 4 | Insider transaction | Mar 4, 2025 | Feb 28, 2025 |
| 4 | Insider transaction | Mar 4, 2025 | Feb 28, 2025 |
| 4 | Insider transaction | Mar 4, 2025 | Feb 28, 2025 |
| 4 | Insider transaction | Mar 4, 2025 | Feb 28, 2025 |
| 4 | Insider transaction | Mar 4, 2025 | Feb 28, 2025 |
| 4 | Insider transaction | Feb 19, 2025 | Feb 18, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Feb 12, 2025 | — |
| 4 | Insider transaction | Feb 5, 2025 | Feb 4, 2025 |
| 4 | Insider transaction | Feb 3, 2025 | Jan 31, 2025 |
| 4 | Insider transaction | Jan 7, 2025 | Jan 6, 2025 |
| 3 | Initial insider ownership | Jan 6, 2025 | Jan 3, 2025 |
| 4 | Insider transaction | Dec 5, 2024 | Dec 4, 2024 |
| 3 | Initial insider ownership | Nov 22, 2024 | Nov 6, 2024 |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 12, 2024 | — |
| 4 | Insider transaction | Nov 6, 2024 | Nov 5, 2024 |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 4, 2024 | — |
| SC 13G | Ownership over 5% (passive) | Oct 25, 2024 | — |
| 4 | Insider transaction | Oct 7, 2024 | Oct 4, 2024 |
| 4 | Insider transaction | Sep 5, 2024 | Sep 4, 2024 |
| 4 | Insider transaction | Sep 5, 2024 | Sep 4, 2024 |
| 4 | Insider transaction | Sep 5, 2024 | Sep 4, 2024 |
| 4 | Insider transaction | Sep 5, 2024 | Sep 4, 2024 |
| 4 | Insider transaction | Aug 8, 2024 | Aug 6, 2024 |
| 4 | Insider transaction | Jul 31, 2024 | Jul 30, 2024 |
| 4 | Insider transaction | Jul 9, 2024 | Jul 5, 2024 |
| SC 13G/A | Amended ownership over 5% (passive) | Jul 8, 2024 | — |
| 4 | Insider transaction | Jun 7, 2024 | Jun 5, 2024 |
| 4 | Insider transaction | Jun 6, 2024 | Jun 4, 2024 |
| 4 | Insider transaction | Jun 6, 2024 | Jun 4, 2024 |
| 4 | Insider transaction | Jun 4, 2024 | May 31, 2024 |
| 4 | Insider transaction | May 30, 2024 | May 29, 2024 |
| 4 | Insider transaction | May 30, 2024 | May 29, 2024 |
| 4 | Insider transaction | May 30, 2024 | May 29, 2024 |
| 4 | Insider transaction | May 30, 2024 | May 29, 2024 |
| 4 | Insider transaction | May 30, 2024 | May 29, 2024 |
| 4 | Insider transaction | May 30, 2024 | May 29, 2024 |
| 4 | Insider transaction | May 30, 2024 | May 29, 2024 |
| SC 13G | Ownership over 5% (passive) | May 23, 2024 | — |
| 4 | Insider transaction | May 7, 2024 | May 6, 2024 |
| 4 | Insider transaction | Apr 23, 2024 | Apr 22, 2024 |
| 4 | Insider transaction | Apr 5, 2024 | Apr 4, 2024 |
| 4 | Insider transaction | Mar 6, 2024 | Mar 5, 2024 |
| 4 | Insider transaction | Mar 4, 2024 | Feb 29, 2024 |
| 4 | Insider transaction | Mar 4, 2024 | Feb 29, 2024 |
| 4 | Insider transaction | Mar 4, 2024 | Feb 29, 2024 |
| 4 | Insider transaction | Mar 4, 2024 | Feb 29, 2024 |
| 4 | Insider transaction | Mar 4, 2024 | Feb 29, 2024 |
| 4 | Insider transaction | Mar 4, 2024 | Feb 29, 2024 |
| 4 | Insider transaction | Feb 29, 2024 | Feb 28, 2024 |
| 4 | Insider transaction | Feb 29, 2024 | Feb 28, 2024 |
| 4 | Insider transaction | Feb 29, 2024 | Feb 27, 2024 |
| 4 | Insider transaction | Feb 29, 2024 | Feb 28, 2024 |
| 4 | Insider transaction | Feb 29, 2024 | Feb 28, 2024 |
| 4 | Insider transaction | Feb 29, 2024 | Feb 28, 2024 |
| 4 | Insider transaction | Feb 20, 2024 | Feb 15, 2024 |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 14, 2024 | — |
| SC 13G | Ownership over 5% (passive) | Feb 13, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Feb 12, 2024 | — |
| 4 | Insider transaction | Feb 8, 2024 | Feb 6, 2024 |
| 4 | Insider transaction | Feb 8, 2024 | Feb 6, 2024 |
| 4 | Insider transaction | Jan 25, 2024 | Jan 24, 2024 |
| 4 | Insider transaction | Jan 25, 2024 | Jan 24, 2024 |
| 4 | Insider transaction | Jan 25, 2024 | Jan 24, 2024 |
| 4 | Insider transaction | Jan 25, 2024 | Jan 24, 2024 |
| 4 | Insider transaction | Jan 25, 2024 | Jan 24, 2024 |
| 4 | Insider transaction | Jan 25, 2024 | Jan 24, 2024 |
| SC 13G/A | Amended ownership over 5% (passive) | Jan 25, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Jan 22, 2024 | — |
| 4 | Insider transaction | Jan 8, 2024 | Jan 4, 2024 |
| 4 | Insider transaction | Dec 5, 2023 | Dec 4, 2023 |
| 4 | Insider transaction | Nov 7, 2023 | Nov 6, 2023 |
| 4 | Insider transaction | Oct 5, 2023 | Oct 4, 2023 |
| 4 | Insider transaction | Sep 12, 2023 | Sep 12, 2023 |
| 4 | Insider transaction | Sep 6, 2023 | Sep 5, 2023 |
| 4 | Insider transaction | Sep 5, 2023 | Sep 1, 2023 |
| 4 | Insider transaction | Sep 5, 2023 | Sep 1, 2023 |
| 4 | Insider transaction | Sep 5, 2023 | Sep 1, 2023 |
| 4 | Insider transaction | Sep 1, 2023 | Aug 31, 2023 |
| 3 | Initial insider ownership | Sep 1, 2023 | Aug 31, 2023 |
| 4 | Insider transaction | Aug 8, 2023 | Aug 7, 2023 |
| 4 | Insider transaction | Aug 1, 2023 | Jul 28, 2023 |
| SC 13G/A | Amended ownership over 5% (passive) | Jul 10, 2023 | — |
| 4 | Insider transaction | Jul 6, 2023 | Jul 5, 2023 |
| 4 | Insider transaction | Jun 12, 2023 | Jun 8, 2023 |
| 4 | Insider transaction | Jun 7, 2023 | Jun 5, 2023 |
| 4 | Insider transaction | Jun 5, 2023 | Jun 2, 2023 |
| 4 | Insider transaction | May 25, 2023 | May 24, 2023 |
| 4 | Insider transaction | May 25, 2023 | May 24, 2023 |
| 4 | Insider transaction | May 25, 2023 | May 24, 2023 |
| 4 | Insider transaction | May 25, 2023 | May 24, 2023 |
| 4 | Insider transaction | May 25, 2023 | May 24, 2023 |
| 4 | Insider transaction | May 25, 2023 | May 24, 2023 |
| 4 | Insider transaction | May 25, 2023 | May 24, 2023 |
| 4 | Insider transaction | May 5, 2023 | May 4, 2023 |
| 4 | Insider transaction | Apr 24, 2023 | Apr 20, 2023 |
| 4 | Insider transaction | Apr 5, 2023 | Apr 4, 2023 |
| 4 | Insider transaction | Mar 7, 2023 | Mar 6, 2023 |
| 4 | Insider transaction | Mar 2, 2023 | Feb 28, 2023 |
| 4 | Insider transaction | Mar 2, 2023 | Feb 28, 2023 |
Showing 200 filings, the most recent 200. Main filings leave out insider and ownership forms such as Form 4; choose a type above to see them. Each form opens on SEC.gov. Older filings are on SEC EDGAR.
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Company profile
- Industry
- Pharmaceutical Preparations (SIC 2834)
- Listed as
- KPTI (Nasdaq)
- Fiscal year ends
- December 31
- Incorporated in
- DE
- Headquarters
- Newton, MA
- SEC filer status
- Non-accelerated filer, Smaller reporting company
- SEC CIK
- 1503802
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Source: SEC EDGAR filings. This is company-reported data, not investment advice.