Karyopharm Therapeutics Inc. SEC filings KPTI
Karyopharm Therapeutics Inc. has 1,001 filings in SEC EDGAR's recent list, going back to Apr 2, 2015. Its latest annual report, Form ARS, was filed on Apr 13, 2026 for the period ended Dec 31, 2025. The latest quarterly report (Form 10-Q) was filed on Aug 13, 2026, covering the quarter ended Jun 30, 2026. The most recent current report (Form 8-K) was filed on Nov 5, 2026 (listing notice). The company's fiscal year ends on December 31.
| Form | Description | Filed | Period |
|---|---|---|---|
| 8-K |
Current report
Listing notice
|
Nov 5, 2026 | Nov 4, 2026 |
| 8-K |
Current report
Material agreement, Bankruptcy, New debt, Regulation FD disclosure, Other events
|
Nov 3, 2026 | Nov 2, 2026 |
| 8-K |
Current report
Regulation FD disclosure
|
Nov 2, 2026 | Nov 2, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Oct 28, 2026 | — |
| 8-K |
Current report
Other events
|
Oct 22, 2026 | Oct 22, 2026 |
| 4 | Insider transaction | Oct 19, 2026 | Oct 16, 2026 |
| 8-K |
Current report
Other events
|
Oct 14, 2026 | Oct 13, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Oct 8, 2026 | — |
| 4 | Insider transaction | Oct 2, 2026 | Oct 1, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Sep 25, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Sep 25, 2026 | — |
| 8-K |
Current report
Change to shareholder rights, Bylaw or fiscal year change
|
Sep 18, 2026 | Sep 17, 2026 |
| 8-K |
Current report
Material agreement, Unregistered share sale, Other events
|
Sep 11, 2026 | Sep 10, 2026 |
| SCHEDULE 13G | Ownership over 5% (passive) | Sep 4, 2026 | — |
| 4 | Insider transaction | Sep 2, 2026 | Sep 1, 2026 |
| 8-K |
Current report
Other events
|
Aug 31, 2026 | Aug 31, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 14, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 14, 2026 | — |
| 10-Q | Quarterly report | Aug 13, 2026 | Jun 30, 2026 |
| 8-K |
Current report
Results of operations
|
Aug 13, 2026 | Aug 13, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 12, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Aug 11, 2026 | — |
| 8-K |
Current report
Other events
|
Jul 31, 2026 | Jul 30, 2026 |
| 4 | Insider transaction | Jul 30, 2026 | Jul 28, 2026 |
| SCHEDULE 13G | Ownership over 5% (passive) | Jul 28, 2026 | — |
| 8-K |
Current report
Officer or director change
|
Jul 17, 2026 | Jul 13, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Jun 5, 2026 | — |
| 8-K |
Current report
Officer or director change, Shareholder vote results
|
May 28, 2026 | May 21, 2026 |
| S-8 | Employee stock plan registration | May 27, 2026 | — |
| S-8 | Employee stock plan registration | May 27, 2026 | — |
| 4 | Insider transaction | May 26, 2026 | May 21, 2026 |
| 4 | Insider transaction | May 26, 2026 | May 21, 2026 |
| 4 | Insider transaction | May 26, 2026 | May 21, 2026 |
| 4 | Insider transaction | May 26, 2026 | May 21, 2026 |
| 4 | Insider transaction | May 26, 2026 | May 21, 2026 |
| 4 | Insider transaction | May 26, 2026 | May 21, 2026 |
| SCHEDULE 13G | Ownership over 5% (passive) | May 15, 2026 | — |
| 4 | Insider transaction | May 15, 2026 | May 13, 2026 |
| 4 | Insider transaction | May 15, 2026 | May 13, 2026 |
| 4 | Insider transaction | May 15, 2026 | May 13, 2026 |
| 4 | Insider transaction | May 15, 2026 | May 13, 2026 |
| 4 | Insider transaction | May 15, 2026 | May 13, 2026 |
| 4 | Insider transaction | May 15, 2026 | May 13, 2026 |
| SCHEDULE 13G | Ownership over 5% (passive) | May 15, 2026 | — |
| EFFECT | Filing | May 14, 2026 | — |
| EFFECT | Filing | May 14, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | May 14, 2026 | — |
| 10-Q | Quarterly report | May 14, 2026 | Mar 31, 2026 |
| 8-K |
Current report
Results of operations
|
May 14, 2026 | May 14, 2026 |
| SCHEDULE 13G | Ownership over 5% (passive) | May 13, 2026 | — |
| CORRESP | Letter to the SEC | May 12, 2026 | — |
| CORRESP | Letter to the SEC | May 12, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | May 12, 2026 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | May 11, 2026 | — |
| UPLOAD | Letter from the SEC | May 7, 2026 | — |
| UPLOAD | Letter from the SEC | May 7, 2026 | — |
| S-3 | Shelf registration | May 4, 2026 | — |
| S-3 | Shelf registration | May 4, 2026 | — |
| 4 | Insider transaction | Apr 22, 2026 | Apr 21, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Apr 13, 2026 | — |
| ARS | Annual report to shareholders | Apr 13, 2026 | Dec 31, 2025 |
| DEF 14A | Proxy statement | Apr 13, 2026 | Apr 13, 2026 |
| SCHEDULE 13G | Ownership over 5% (passive) | Apr 2, 2026 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Apr 2, 2026 | — |
| 8-K |
Current report
Other events
|
Mar 27, 2026 | Mar 27, 2026 |
| 8-K |
Current report
Material agreement, Unregistered share sale, Regulation FD disclosure, Other events
|
Mar 24, 2026 | Mar 24, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 4 | Insider transaction | Mar 3, 2026 | Mar 2, 2026 |
| 8-K |
Current report
Material agreement, Other events
|
Mar 3, 2026 | Feb 27, 2026 |
| 8-K |
Current report
Shareholder vote results
|
Feb 19, 2026 | Feb 18, 2026 |
| 4 | Insider transaction | Feb 19, 2026 | Feb 17, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 17, 2026 | — |
| 10-K | Annual report | Feb 13, 2026 | Dec 31, 2025 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Feb 12, 2026 | — |
| 8-K |
Current report
Results of operations
|
Feb 12, 2026 | Feb 12, 2026 |
| SCHEDULE 13G | Ownership over 5% (passive) | Feb 10, 2026 | — |
| 4 | Insider transaction | Feb 9, 2026 | Feb 5, 2026 |
| 4 | Insider transaction | Feb 4, 2026 | Feb 3, 2026 |
| 4 | Insider transaction | Feb 3, 2026 | Jan 31, 2026 |
| 4 | Insider transaction | Feb 3, 2026 | Jan 31, 2026 |
| 4 | Insider transaction | Feb 3, 2026 | Jan 31, 2026 |
| 4 | Insider transaction | Feb 3, 2026 | Jan 31, 2026 |
| 4 | Insider transaction | Feb 3, 2026 | Jan 31, 2026 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Jan 29, 2026 | — |
| 4 | Insider transaction | Jan 29, 2026 | Jan 27, 2026 |
| 4 | Insider transaction | Jan 22, 2026 | Jan 21, 2026 |
| 8-K |
Current report
Results of operations, Other events
|
Jan 12, 2026 | Jan 12, 2026 |
| DEF 14A | Proxy statement | Jan 9, 2026 | Feb 18, 2026 |
| PRE 14A | Preliminary proxy statement | Dec 30, 2025 | Dec 30, 2025 |
| 424B3 | Prospectus | Nov 24, 2025 | — |
| 424B3 | Prospectus | Nov 24, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Nov 14, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Nov 7, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Nov 3, 2025 | — |
| S-3 | Shelf registration | Nov 3, 2025 | — |
| S-3 | Shelf registration | Nov 3, 2025 | — |
| 10-Q | Quarterly report | Nov 3, 2025 | Sep 30, 2025 |
| 8-K |
Current report
Results of operations
|
Nov 3, 2025 | Nov 3, 2025 |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Oct 30, 2025 | — |
| SCHEDULE 13G | Ownership over 5% (passive) | Oct 17, 2025 | — |
| SCHEDULE 13G/A | Amended ownership over 5% (passive) | Oct 17, 2025 | — |
| 4 | Insider transaction | Oct 16, 2025 | Oct 15, 2025 |
| 4 | Insider transaction | Oct 16, 2025 | Oct 15, 2025 |
| 4 | Insider transaction | Oct 16, 2025 | Oct 15, 2025 |
| 4 | Insider transaction | Oct 16, 2025 | Oct 15, 2025 |
| 4 | Insider transaction | Oct 16, 2025 | Oct 15, 2025 |
| 4 | Insider transaction | Oct 16, 2025 | Oct 15, 2025 |
| 8-K |
Current report
Material agreement, New debt, Other events
|
Oct 14, 2025 | Oct 10, 2025 |
| 8-K |
Current report
Material agreement, Results of operations, New debt, Unregistered share sale, Officer or director change, Regulation FD disclosure, Other events
|
Oct 8, 2025 | Oct 7, 2025 |
| 4 | Insider transaction | Oct 3, 2025 | Oct 1, 2025 |
| 4 | Insider transaction | Sep 16, 2025 | Sep 12, 2025 |
| 4 | Insider transaction | Sep 16, 2025 | Sep 12, 2025 |
| 4 | Insider transaction | Sep 16, 2025 | Sep 12, 2025 |
| 4 | Insider transaction | Sep 16, 2025 | Sep 12, 2025 |
| 4 | Insider transaction | Sep 16, 2025 | Sep 12, 2025 |
| 4 | Insider transaction | Sep 16, 2025 | Sep 12, 2025 |
| 8-K |
Current report
Officer or director change
|
Sep 11, 2025 | Sep 5, 2025 |
| 4 | Insider transaction | Sep 4, 2025 | Sep 3, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Aug 14, 2025 | — |
| S-8 | Employee stock plan registration | Aug 11, 2025 | — |
| 10-Q | Quarterly report | Aug 11, 2025 | Jun 30, 2025 |
| 8-K |
Current report
Results of operations
|
Aug 11, 2025 | Aug 11, 2025 |
| 4 | Insider transaction | Jul 30, 2025 | Jul 29, 2025 |
| 4 | Insider transaction | Jul 23, 2025 | Jul 22, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Jul 16, 2025 | — |
| 8-K |
Current report
Regulation FD disclosure
|
Jul 11, 2025 | Jul 11, 2025 |
| 8-K |
Current report
Officer or director change, Shareholder vote results
|
May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 4 | Insider transaction | May 29, 2025 | May 28, 2025 |
| 10-Q | Quarterly report | May 12, 2025 | Mar 31, 2025 |
| 8-K |
Current report
Results of operations
|
May 12, 2025 | May 12, 2025 |
| 4 | Insider transaction | May 7, 2025 | May 6, 2025 |
| 4 | Insider transaction | Apr 24, 2025 | Apr 23, 2025 |
| ARS | Annual report to shareholders | Apr 14, 2025 | Dec 31, 2024 |
| DEFA14A | Additional proxy material | Apr 14, 2025 | — |
| DEF 14A | Proxy statement | Apr 14, 2025 | May 28, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Apr 10, 2025 | — |
| 4 | Insider transaction | Apr 7, 2025 | Apr 4, 2025 |
| 4 | Insider transaction | Mar 6, 2025 | Mar 4, 2025 |
| 4 | Insider transaction | Mar 6, 2025 | Mar 4, 2025 |
| 4 | Insider transaction | Mar 6, 2025 | Mar 4, 2025 |
| 4 | Insider transaction | Mar 6, 2025 | Mar 4, 2025 |
| 4 | Insider transaction | Mar 6, 2025 | Mar 4, 2025 |
| 4 | Insider transaction | Mar 6, 2025 | Mar 4, 2025 |
| 4 | Insider transaction | Mar 4, 2025 | Feb 28, 2025 |
| 4 | Insider transaction | Mar 4, 2025 | Feb 28, 2025 |
| 4 | Insider transaction | Mar 4, 2025 | Feb 28, 2025 |
| 4 | Insider transaction | Mar 4, 2025 | Feb 28, 2025 |
| 4 | Insider transaction | Mar 4, 2025 | Feb 28, 2025 |
| 4 | Insider transaction | Mar 4, 2025 | Feb 28, 2025 |
| 8-K |
Current report
Change to shareholder rights, Bylaw or fiscal year change
|
Feb 24, 2025 | Feb 24, 2025 |
| 4 | Insider transaction | Feb 19, 2025 | Feb 18, 2025 |
| 10-K | Annual report | Feb 19, 2025 | Dec 31, 2024 |
| 8-K |
Current report
Results of operations
|
Feb 19, 2025 | Feb 19, 2025 |
| SCHEDULE 13G | Ownership over 5% (passive) | Feb 12, 2025 | — |
| 4 | Insider transaction | Feb 5, 2025 | Feb 4, 2025 |
| 4 | Insider transaction | Feb 3, 2025 | Jan 31, 2025 |
| 8-K |
Current report
Officer or director change
|
Jan 31, 2025 | Jan 27, 2025 |
| 8-K |
Current report
Shareholder vote results
|
Jan 30, 2025 | Jan 30, 2025 |
| 8-K |
Current report
Results of operations
|
Jan 13, 2025 | Jan 13, 2025 |
| 4 | Insider transaction | Jan 7, 2025 | Jan 6, 2025 |
| 3 | Initial insider ownership | Jan 6, 2025 | Jan 3, 2025 |
| 8-K |
Current report
Officer or director change
|
Jan 2, 2025 | Jan 2, 2025 |
| DEF 14A | Proxy statement | Dec 16, 2024 | Jan 30, 2025 |
| PRE 14A | Preliminary proxy statement | Dec 5, 2024 | Dec 5, 2024 |
| 4 | Insider transaction | Dec 5, 2024 | Dec 4, 2024 |
| 8-K |
Current report
Regulation FD disclosure
|
Dec 3, 2024 | Dec 3, 2024 |
| 3 | Initial insider ownership | Nov 22, 2024 | Nov 6, 2024 |
| 8-K |
Current report
Officer or director change
|
Nov 20, 2024 | Nov 20, 2024 |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 14, 2024 | — |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 12, 2024 | — |
| 8-K |
Current report
Material agreement
|
Nov 8, 2024 | Nov 5, 2024 |
| 4 | Insider transaction | Nov 6, 2024 | Nov 5, 2024 |
| S-8 | Employee stock plan registration | Nov 5, 2024 | — |
| 10-Q | Quarterly report | Nov 5, 2024 | Sep 30, 2024 |
| 8-K |
Current report
Results of operations
|
Nov 5, 2024 | Nov 5, 2024 |
| SC 13G/A | Amended ownership over 5% (passive) | Nov 4, 2024 | — |
| 8-K |
Current report
Regulation FD disclosure, Other events
|
Oct 31, 2024 | Oct 31, 2024 |
| SC 13G | Ownership over 5% (passive) | Oct 25, 2024 | — |
| 4 | Insider transaction | Oct 7, 2024 | Oct 4, 2024 |
| 8-K |
Current report
Listing notice
|
Sep 17, 2024 | Sep 16, 2024 |
| 4 | Insider transaction | Sep 5, 2024 | Sep 4, 2024 |
| 4 | Insider transaction | Sep 5, 2024 | Sep 4, 2024 |
| 4 | Insider transaction | Sep 5, 2024 | Sep 4, 2024 |
| 4 | Insider transaction | Sep 5, 2024 | Sep 4, 2024 |
| 8-K |
Current report
Officer or director change
|
Aug 29, 2024 | Aug 26, 2024 |
| 4 | Insider transaction | Aug 8, 2024 | Aug 6, 2024 |
| 10-Q | Quarterly report | Aug 6, 2024 | Jun 30, 2024 |
| 8-K |
Current report
Results of operations
|
Aug 6, 2024 | Aug 6, 2024 |
| 4 | Insider transaction | Jul 31, 2024 | Jul 30, 2024 |
| SC TO-I/A | Filing | Jul 19, 2024 | — |
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Company profile
- Industry
- Pharmaceutical Preparations (SIC 2834)
- Listed as
- KPTI (Nasdaq)
- Fiscal year ends
- December 31
- Incorporated in
- DE
- Headquarters
- Newton, MA
- SEC filer status
- Non-accelerated filer, Smaller reporting company
- SEC CIK
- 1503802
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Source: SEC EDGAR filings. This is company-reported data, not investment advice.