In fiscal 2025, which ended Sep 30, 2025, Twist Bioscience Corporation reported revenue of $376.6 million, up 20.3% from the year before. It recorded a net loss of $77.7 million. The operating loss came to $136.3 million, an operating margin of -36.2%. Diluted earnings per share were -$1.30. Over the twelve months ended Jun 30, 2026, revenue was $431.8 million and the net loss was $136.7 million. Across the 7 fiscal years shown, revenue grew from $54.4 million in fiscal 2019 to $376.6 million in fiscal 2025, about 38.1% a year.
USD in millions, except per-share amounts and margins. The percent under a figure is the change from the year before.
| Line |
FY 2026
Jun 30, 2026
|
FY 2025
Sep 30, 2025
|
FY 2024
Sep 30, 2024
|
FY 2023
Sep 30, 2023
|
FY 2022
Sep 30, 2022
|
FY 2021
Sep 30, 2021
|
FY 2020
Sep 30, 2020
|
FY 2019
Sep 30, 2019
|
|---|---|---|---|---|---|---|---|---|
| Revenue |
432
+19.2%
|
377
+20.3%
|
313
+27.7%
|
245
+20.4%
|
204
+53.8%
|
132
+46.9%
|
90
+65.7%
|
54
|
| Cost of revenue |
207
+12.8%
|
186
+3.3%
|
180
+15.6%
|
155
+30.2%
|
119
+48.0%
|
81
+31.3%
|
61
+29.5%
|
47
|
| Gross profit |
224
+25.8%
|
191
+43.2%
|
133
+48.6%
|
90
+6.5%
|
84
+62.9%
|
52
+80.2%
|
29
+312.3%
|
7
|
| Research and development |
72
-14.9%
|
80
-11.6%
|
91
-15.0%
|
107
-11.1%
|
120
+74.2%
|
69
+60.6%
|
43
+20.5%
|
36
|
| Selling, general and administrative |
290
+22.8%
|
247
+13.1%
|
218
+15.1%
|
190
-10.9%
|
213
+56.7%
|
136
+31.6%
|
103
+28.9%
|
80
|
| Operating expenses |
—
|
327
|
—
|
—
|
—
|
—
|
—
|
116
|
| Operating income |
-145
-1.8%
|
-136
+38.3%
|
-221
-1.7%
|
-217
+7.5%
|
-235
-53.7%
|
-153
-9.0%
|
-140
-28.7%
|
-109
|
| Pretax income |
-136
-60.2%
|
-77
+63.0%
|
-208
-2.3%
|
-203
+10.9%
|
-228
-48.2%
|
-154
-10.4%
|
-140
-30.0%
|
-107
|
| Income tax |
1
+136.1%
|
1
+28.4%
|
1
-51.4%
|
1
+111.1%
|
-10
-439.4%
|
-2
-605.2%
|
0
+30.8%
|
0
|
| Net income |
-137
-60.5%
|
-78
+62.8%
|
-209
-2.0%
|
-205
+6.1%
|
-218
-43.2%
|
-152
-8.7%
|
-140
-30.0%
|
-108
|
| Basic EPS |
-2.23
-55.2%
|
-1.30
+63.9%
|
-3.60
+0.0%
|
-3.60
+10.9%
|
-4.04
|
—
|
—
|
—
|
| Diluted EPS |
-2.23
-55.2%
|
-1.30
+63.9%
|
-3.60
+0.0%
|
-3.60
+10.9%
|
-4.04
|
—
|
—
|
—
|
| Weighted average shares, basic |
61
+3.4%
|
60
+3.1%
|
58
+2.0%
|
57
+5.6%
|
54
|
—
|
—
|
—
|
| Weighted average shares, diluted |
61
+3.4%
|
60
+3.1%
|
58
+2.0%
|
57
+5.6%
|
54
|
—
|
—
|
—
|
| Other measures | ||||||||
| Depreciation and amortization |
25
-0.5%
|
25
-20.9%
|
31
+7.2%
|
29
+77.5%
|
17
+69.4%
|
10
+46.0%
|
7
+9.3%
|
6
|
| EBITDA |
-120
-2.3%
|
-111
+41.2%
|
-189
-0.8%
|
-188
+13.9%
|
-218
-52.7%
|
-143
-7.2%
|
-133
-29.8%
|
-103
|
| Interest coverage |
—
|
—
|
-7,614.86x
|
—
|
—
|
—
|
—
|
—
|
| Margins | ||||||||
| Gross margin |
51.97%
|
50.72%
|
42.61%
|
36.61%
|
41.38%
|
39.08%
|
31.85%
|
12.80%
|
| Operating margin |
-33.58%
|
-36.18%
|
-70.56%
|
-88.60%
|
-115.33%
|
-115.41%
|
-155.47%
|
-200.15%
|
| Pretax margin |
-31.46%
|
-20.43%
|
-66.51%
|
-83.01%
|
-112.14%
|
-116.39%
|
-154.88%
|
-197.44%
|
| Profit margin |
-31.66%
|
-20.63%
|
-66.69%
|
-83.48%
|
-107.02%
|
-114.94%
|
-155.31%
|
-197.98%
|
| EBITDA margin |
-27.70%
|
-29.58%
|
-60.52%
|
-76.64%
|
-107.22%
|
-108.04%
|
-148.06%
|
-188.91%
|
How these figures are calculated
Annual columns are full-year amounts from the annual report (Form 10-K, 20-F, or 40-F). If a company restates a year, the latest filed number is shown. USD in millions, except per-share amounts and margins. Weighted average shares are in millions. Interest expense and finance costs are positive costs. A negative amount on a gain (loss) or income (expense) line is a loss or an expense. EBITDA is operating income plus depreciation and amortization. Interest coverage is operating income divided by interest expense. The first column is the trailing twelve months through the latest quarter. More on our methodology.
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Company profile
- Industry
- Biological Products, (No Diagnostic Substances) (SIC 2836)
- Listed as
- TWST (Nasdaq)
- Fiscal year ends
- September 30
- Incorporated in
- DE
- Headquarters
- South San Francisco, CA
- SEC filer status
- Large accelerated filer
- SEC CIK
- 1581280
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Source: SEC EDGAR filings. This is company-reported data, not investment advice.