Alnylam Pharmaceuticals, Inc. revenue by segment ALNY

Annual Quarterly

Alnylam Pharmaceuticals, Inc. splits its revenue into 7 lines in its filings. The largest line in fiscal 2025, which ended Dec 31, 2025 was Amvuttra at $2.3 billion, 62% of the total.

USD in millions. The percent under a figure is the change from the year before.

Line	FY 2026 Sep 30, 2026	FY 2025 Dec 31, 2025	FY 2024 Dec 31, 2024	FY 2023 Dec 31, 2023	FY 2022 Dec 31, 2022	FY 2021 Dec 31, 2021	FY 2020 Dec 31, 2020	FY 2019 Dec 31, 2019	FY 2018 Dec 31, 2018	FY 2017 Dec 31, 2017	FY 2016 Dec 31, 2016
Revenue	5,013	3,714	2,248	1,828	1,037	844	493	220	75	—	—
Amvuttra	3,859 +117.5% share 77.0%	2,314 +138.4% share 62.3%	970 +74.0% share 43.2%	558 +494.7% share 30.5%	94 share 9.0%	—	—	—	—	—	—
Collaborations	242 -61.0% share 4.8%	553 +8.5% share 14.9%	510 -6.6% share 22.7%	546 +304.8% share 29.9%	135 -25.4% share 13.0%	181 share 21.4%	—	—	—	—	—
GIVLAARI	340 +18.9% share 6.8%	308 +20.6% share 8.3%	256 +16.7% share 11.4%	219 +26.6% share 12.0%	173 +35.5% share 16.7%	128 +131.9% share 15.1%	55 +36637.3% share 11.2%	0 share 0.1%	—	—	—
OXLUMO	206 +10.9% share 4.1%	191 +14.6% share 5.2%	167 +52.1% share 7.4%	110 +57.4% share 6.0%	70 +17.1% share 6.7%	60 +17793.7% share 7.1%	0 share 0.1%	—	—	—	—
Royalty	277 +86.9% share 5.5%	174 +89.6% share 4.7%	92 +125.9% share 4.1%	41 +396.9% share 2.2%	8 +583.7% share 0.8%	1 share 0.1%	—	—	—	—	—
ONPATTRO	90 -54.2% share 1.8%	173 -31.7% share 4.7%	253 -28.7% share 11.2%	355 -36.4% share 19.4%	558 +17.5% share 53.7%	475 +55.1% share 56.2%	306 +84.0% share 62.1%	166 share 75.7%	—	—	—
Product	—	—	—	—	—	—	—	—	13 share 16.7%	—	—

How these figures are calculated

Annual columns are full-year amounts from the annual report (Form 10-K, 20-F, or 40-F). If a company restates a year, the latest filed number is shown. USD in millions. Each group is a separate split of total revenue, so the groups are not added together. Share of revenue is that line divided by total revenue. The first column adds the latest year-to-date segment amount to the last fiscal year and subtracts the year-ago year-to-date amount. More on our methodology.

Company profile

Industry: Pharmaceutical Preparations (SIC 2834)
Listed as: ALNY (Nasdaq)
Fiscal year ends: December 31
Headquarters: Cambridge, MA
SEC filer status: Large accelerated filer
SEC CIK: 1178670
Former names: ALNYLAM PHARMACEUTICALS INC (until Jul 2, 2004)

Other Pharmaceutical Preparations companies

All 570 Pharmaceutical Preparations companies

Source: SEC EDGAR filings. This is company-reported data, not investment advice.